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Stanford reports research funding from the National Institutes of Health

Glucocorticoids decrease the production of glucagon-like peptide-1 at the transcriptional level in intestinal L-cells

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The same study showed that patients taking higher doses and remaining adherent achieved weight loss comparable to clinical trials

These results may have limited generalizability due to bias introduced by the studys design, including the treatment setting (ie, a neuroophthalmology clinic) and potential worse baseline health in patients taking semaglutide compared with matched controls