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Beyond obesity and type 2 diabetes, the therapeutic potential of GLP-1 RAs extends to a range of conditions such as cardiovascular disease, liver disease, neurodegenerative disease, and substance abuse disorders

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4 Confounding factors Although the aforementioned studies show that GLP-1R agonists and/or GLP-1 modulate the responses to alcohol and addictive drugs, various limitations and confounding factors influence the conclusions that can be drawn from the acquired data

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Association of GLP-1 RAs with suicide or suicide attempts In intention-to-treat (ITT) analysis the GLP-1 RA vs SGLT-2 inhibitor cohort median follow-up time was 1 year [13] for new GLP-1 RA users and 2 years [13] for new SGLT-2 inhibitor users