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It suggests that 68Ga may be a nuclide probe with great potential for molecular imaging of GLP-1R

This methodical progression serves multiple functions: Allows physiological adaptation to receptor stimulation Reduces treatment discontinuation from gastrointestinal adverse events Enables monitoring of metabolic markers at each dose level The gradual approach addresses common tolerability challenges associated with incretin-based medications, particularly nausea, vomiting, and diarrhea that can occur with rapid dose introduction

In DIO mice, a GLP-1R/GIPR co-agonist supplemented by an injection of a GcgR agonist resulted in a greater decrease in body weight and food intake than the co-agonist alone [92]

You can also add Colace if additional intervention is needed

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