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Hard outcome (longevity): In a target trial emulation of 438 women with T2D, metformin initiation was linked to 30% lower risk of death before age 90 vs

Our major concern is the unbalance and inappropriate reductions in calorie or energy intake associated with these weight loss drugs," said Cooper, associate director of the UCI Institute for Clinical and Translational Science and interim director of the UCI Institute for Precision Health

You had significant GI side effects on tirzepatide: If titrating tirzepatide was genuinely difficult, adding a third mechanism is unlikely to make that easier

The goal is to lose weight at a healthy pace while keeping a positive relationship with foodwithout overthinking every bite

showed that liraglutide 3.0 mg/day significantly decreased body weight, BMI, WC and Waist to Hip ratio (W/H) compared with the placebo group [62]
