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Description
The GLP-1 agonist exendin-4 attenuates self-administration of sweetened fat on fixed and progressive ratio schedules of reinforcement in rats

The trial also reported dose-dependent increases in heart rate that peaked at 24 weeks and declined thereafter

Side effects are severe or persistent: Mild, temporary side effects are common

Li H, Xu J, Fan X

Earlier studies, including a 2018 double-blind RCT of 228 adults with functional constipation, found no significant difference between HN019 and placebo in primary outcomes overall, but a post-hoc subgroup analysis in adults with very low baseline stool frequency (fewer than 3 bowel movements per week) showed a physiologically relevant increase in bowel movement frequency in the HN019 groups vs
