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GLP-1 medications require a washout period before pregnancy but do not carry the same level of birth defect risk

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Variants in GLP1R (the GLP-1 receptor itself), GIPR (the GIP receptor relevant to tirzepatide's dual mechanism), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide

Structural and molecular conservation of glucagon-like Peptide-1 and its receptor confers selective ligand-receptor interaction