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The HFD-SEMA group exhibited improved astrocyte coverage on vessels

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Human clinical studies report measurable reductions in HbA1c levels, body-weightrelated endpoints, and improved insulin sensitivity markers compared to placebo-controlled groups

Compared to baseline, DIO mice assumed phylogenetically similar gut bacterial compositional changes following liraglutide and GUB09-145 treatment, characterized by discrete shifts in low-abundant species and related bacterial metabolic pathways