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Considering this biphasic weight pattern in PD, the dual action of GLP-1 RAs, reducing insulin resistance while inducing weight loss, raises important considerations regarding their long-term metabolic effects in PD patients with varying phenotypes and nutritional profiles

Short-acting GLP-1 RAs such as exenatide BID (Byetta) and lixisenatide (Adlyxin) can significantly delay gastric emptying processes in vivo

These mechanisms collectively contribute to improved vascular health and reduced cardiometabolic burden

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Your prescribed dose depends on multiple factors including your current HbA1c, body weight, renal function, other medications, and treatment goals