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They are highly effective for many people but they come with limitations. With the right supervision, glucagon-like peptide-1 receptor agonists (GLP-1s) can be part of a staged approach to help you reach your weight loss goals

Discontinue Mounjaro, Ozempic, or Rybelsus 2 months before trying to conceive, and Lusefi or Metformin 1 month before trying to conceive

Retatrutide (Phase 3 Clinical Trials, 2026) Retatrutide entered Phase 3 trials under the TRIUMPH program

Like Ozempic, Rybelsus is only FDA-approved to treat type 2 diabetes, but it can be prescribed off-label for weight loss

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