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Phase 2 SYNERGY-NASH data showed significant reductions in liver fat fraction and NASH resolution rates

doi: 10.1007/s00125-016-4061-x

Serious but Rare Side Effects Both medications carry warnings for more serious but uncommon side effects, occurring in less than 1-2% of patients: Pancreatitis (inflammation of the pancreas) Kidney problems Severe allergic reactions Thyroid tumors (seen in animal studies) Gastroparesis (delayed stomach emptying) Serious stomach issues Vision problems in some diabetics Retatrutides side effect profile appears similar to that of other incretin-based medications, though long-term safety data remains limited due to its investigational status

Semaglutide works with one signal, making it a single agonist, specifically a GLP-1 receptor agonist (Glucagon-Like Peptide-1)

(2026, Clinical Obesity ) reviewed six studies covering 480,825 adults and found: vitamin D deficiency in 13.6% at 12 months, iron depletion with 2630% lower ferritin versus comparators, and rising B vitamin deficiency rates over treatment duration