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Description
Those who responded well to moderate doses (4-8mg) did not necessarily need to escalate to the maximum 12mg
Novo Nordisk achieved this with semaglutide, a molecule structurally optimized for extreme durability

The 2 mg 4 mg 8 mg 12 mg protocol was the most effective and forms the basis for Phase 3 trials (TRIUMPH programme)

This lowers the cost per unit as purchase quantities grow over time
That structural problem requires treatment