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Being obese with a body mass index of over 25 kg/m also increases the risk of diabetes

While most are mild and self-limited, a subset are clinically significant and relevant to emergency medicine

According to American Gastroenterological Association guidelines, osmotic laxatives like polyethylene glycol (PEG 3350) are recommended as first-line treatment for tirzepatide-induced constipation, as they are generally safe for regular use and effectively draw water into the colon to soften stools

The Canadian Institutes of Health Research (CIHR) and Diabetes Canada supported this work (ARJ-162628, Project Grant 156136 and New Investigator award to EEM and Project Grant 148634 and New Investigator award 141981 to MDF)

Semaglutide Important Safety Information Regarding Compounded Semaglutide Products Please be aware that compounded drugs are not FDA-approved and do not undergo clinical studies to evaluate for safety and efficacy