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In three separate SUSTAIN trials, semaglutide 1 mg conferred a greater weight loss among adults with type 2 diabetes than exenatide 2 mg (Bydureon, AstraZeneca), dulaglutide 1.5 mg (Trulicity, Eli Lilly) and liraglutide 1.8 mg (Saxenda, Novo Nordisk)

Both use gradual dose titration to minimize gastrointestinal side effects

However, excessive length may impede ligand to bind and activate receptor

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The success of GLP-1/GIP and GLP-1/GCG dual agonists thus far suggests that GLP-1/GIP/GCG may provide even greater WL compared to dual agonist therapies