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The metabolic enhancements seem to be partially independent of weight reduction, indicating direct effects on various tissues that express GLP-1 receptors

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Keidar A, Hershkop KJ, Marko L, Schweiger C, Hecht L, Bartov N, Kedar A, Weiss R

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To this end, we employed either a global (whole cell) or a mitochondrially-restricted PKA biosensor expressed at the outer mitochondrial membrane (OMM) 27 (Supplementary Fig