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In PDB ID 1nu8, Diprotin A forms a tetrahedral intermediate, where the C atom of the carbonyl group of Pro2 in Diprotin A was found in a tetrahedral configuration (grey ball in Figure 5) covalently linked to Ser630

A recent meta-analysis of 157 randomized controlled trials (RCTs) indicated that dipeptidyl peptidase-4 inhibitors do not affect overall cancer risk and are associated with a significantly reduced risk of colorectal cancer [6]

Elucidating the underlying cellular and molecular mechanisms could potentially usher in the development of new generations of incretin mimetics with enhanced efficacy and fewer adverse effects

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