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Some observational studies indicate that individuals with a lower body mass index (BMI) may have a slightly increased risk of developing endometriosis, whilst obesity appears to have a more variable association

Available strengths may include varying milligram ratios (e.g., 20/25 mg, 40/50 mg, 40/100 mg), offering flexibility in clinical titration

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This might involve optimising other oral medications, considering alternative injectable therapies, or intensifying lifestyle interventions

Patient enrollment in clinical studies is also based mainly on baseline A1C, and treatment of a comparator is sometimes chosen unrelated to its pathophysiologic effect on hyperglycemia