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In the central nervous system, agents like exedin-4 and liraglutide reduce neuroinflammation by inhibiting microglial activation and cytokine production (IL-1, IL-6, TNF- ), while preserving neuronal integrity and preventing cognitive dysfunction associated with sepsis
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GLP-1 research peptides are compounds studied in relation to glucagon-like peptide-1 receptor pathways, incretin signalling and metabolic research models

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The lack of data had previously led societies to rely on expert opinion for guidance