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Several factors increase your likelihood significantly: History of GERD or acid reflux , even if it was well-controlled before starting tirzepatide Hiatal hernia , which already weakens the lower esophageal sphincter Obesity , which increases abdominal pressure (though this improves as you lose weight on the medication) Smoking , which relaxes the esophageal sphincter Certain medications like NSAIDs, calcium channel blockers, or bisphosphonates that independently increase reflux risk Eating large meals or eating close to bedtime If you had occasional heartburn before starting tirzepatide, the medication can amplify it significantly during the early weeks

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Most people find that as they become more comfortable with the self-injection process, the frequency of these marks decreases

[0031] Both pharmacokinetics and pharmacodynamics profiles after intranasal administration of semaglutide pharmaceutical compositions (PT-N01 to PT-N06) in rats, rabbits and beagle dogs are described in EXAMPLEs 3 to 5