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Men using both therapies should establish baseline cardiovascular metrics before starting and schedule periodic monitoring, especially during the first three months of combined treatment

Global effect of cardiovascular risk factors on lifetime estimates

The EMPA-HEART trial showed reduction in LV mass and systolic BP in HF with reduced ejection fraction (HFrEF) patients, although the effects on N-terminal pro-B-type natriuretic peptide (NT-proBNP) was insignificant.36 The EMPERIAL trials (NCT03448419 and NCT03448406) reported no significant improvements in exercise capacity measured by 6-minute walking distance

[4] While occasional mild leg cramps may not require immediate medical attention, certain features warrant prompt evaluation by your healthcare provider to rule out more serious underlying conditions or complications

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