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Tirzepatide is a dual agonist at GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors and produces enhanced glycemic control and greater weight loss compared to many GLP-1 RAs [34]

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Clinical Evidence on Starting Dose Weight Loss Results Research on GLP-1 receptor agonists demonstrates that even starting doses produce measurable weight loss in the majority of users

Some patients experience significant improvement, others see modest benefits, and some see no improvement or experience adverse effects necessitating treatment discontinuation