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Early dumping is the result of rapid nutrient delivery into the small intestine

44 Interestingly, other macronutrients (for example fatty acids) do not induce proinsulin biosynthesis, in spite of their ability to act as potent secretagogues for insulin secretion

This vagal impairment is a central driver of dysautonomia and Postural Orthostatic Tachycardia Syndrome (POTS), conditions frequently comorbid with Long COVID and ME/CFS

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To gain further insight, a non-compartmental PK analysis was performed using gPKPDSim 74 , which revealed a 3.8-fold slower clearance rate (CL) and a 2.4-fold longer mean residence time (MRT) of QMP compared with WT albumin (Supplementary Table 4)