glp-1 agonists vs bariatric surgery weight loss comparison GLP-1RAs offer comparable to with fewer side effects Interest in Treatment with GLP-1

10.1016/S0140-6736(18)32261-X

Can they help with cholesterol

176,177 When GLP-1 binds to GLP-1R, it triggers the activation of G-proteins, leading to an increase in the intracellular second messenger cAMP

We systematically searched English and Chinese databases, including Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, and Weipu website (VIP), based on the PICOS (Participants, Interventions, Comparisons, Outcomes, Study design) principles

Response rates vary by molecule newer agents such as tirzepatide and semaglutide yield higher responder rates (~86%91%) than older agents such as exenatide or liraglutide (~40%65%) (223) and vary by baseline BMI, sex, and glycemic status, with women and individuals with higher BMI responding better (222, 224)