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Metabolism No major metabolites of empagliflozin were detected in human plasma and the most abundant metabolites were three glucuronide conjugates (2-O-, 3-O-, and 6-O-glucuronide)

While similar GI symptoms may occur with oral anti-diabetic agents, such as metformin and alpha glucosidase inhibitors (flatulence, diarrhea and pain), symptoms improve when the medication is discontinued [68]

Unfortunately, these medications have modest activity and significant potential for toxicity [44]

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While it has been postulated that these two actions are inextricably linked more recent data shows they can indeed be divorced which opens the opportunity for tailored pharmacology that provide food intake reduction without the adverse events typically associated with GLP-1R agonism