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By coupling GLP1-R agonist and GIP agonist together (seen in Tirzepatide), reduced reward-seeking behavior induced by the former may be strengthened by the enhanced mTOR effect of the latter, reinforcing neural circuits involved in executive control and decision-making, potentially counteracting the dysregulated reward pathways seen in addiction (Figure 3) [46,51]

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This result suggests that semaglutide has cardioprotective effect independent of any substantial glucose lowering properties
