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Cagrilintide was designed for stacking
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ACHIEVE-4 (NCT05803421) This trial evaluates orforglipron in patients with type 2 diabetes already treated with basal insulin, assessing whether the addition of an oral GLP-1 agonist can improve glycemic control and reduce insulin requirements

Nature Metabolism, 3, 142148

Based on our prior experience, 22 NanoBiT strategy 23,24 was used in this study to stabilize the GLP-2GLP-2RG s complex and strengthen the interactions between GLP-2R and G, resulting in a cryo-EM structure at a global resolution of 3.0 (Supplementary information, Table S1)
