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Retatrutide should not be used in individuals with a personal or family history of medullary thyroid carcinoma or MEN2 syndrome

First-generation antihistamines like Benadryl and Chlor-Trimeton may be used but can cause drowsiness

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What Trusted Sources and Medical Groups Say About Use While Nursing FDA product labeling for tirzepatide does not provide detailed human milk excretion data and advises clinicians to weigh benefits and risks before using the drug in breastfeeding parents

The observation that dogs with completely denervated gastric pouches retained the inhibition of gastric secretion induced by ingestion of fat led Takashi Kosaka and Robert Kho-Seng Lim in 1930 to hypothesize that fat-mediated inhibition of gastric secretion is mediated by another unidentified intestinal hormone, which they named enterogastrone (i.e