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others with GLP1R variants may show reduced baseline receptor sensitivity, potentially informing GLP-1 dosing decisions

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To correct for this, we performed RNA-seq analysis of hypothalami obtained from animals treated with daily injections of either GLP-1MK-801 or a dose of semaglutide that was equipotent in terms of weight-lowering efficacy over 5 days of treatment, that is, mice had achieved a comparable weight loss and reduction in food intake as that of GLP-1MK-801-treated mice (Extended Data Fig

doi:10.2174/157339913804143225 6

Kidney function support GLP-1s have been associated with reduced albuminuria and slower kidney disease progression in certain populations