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LDL cholesterol also dropped, improving overall lipid balance

For example, a reduction in estrogen can lead to additional abdominal fat and muscle loss

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14.4 Cardiovascular Outcomes Trial of RYBELSUS in Adult Patients with Type 2 Diabetes Mellitus and High Risk of Having a Cardiovascular Event Trial 7 [Semaglutide Cardiovascular Outcomes Trial (SOUL), NCT03914326] was a randomized, double-blind, parallel-group, placebo-controlled trial

These include: Nausea (very common, affecting more than 1 in 10 people) Diarrhoea (very common) Vomiting (common, affecting up to 1 in 10 people) Constipation (common) Abdominal pain (common) Reduced appetite (very common) These gastrointestinal effects typically occur during dose escalation and often diminish over time as the body adjusts to the medication