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These peptides were designed to mimic the action of these hormones (what in pharmacology is called an agonist effect) on the control of glycemia

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This suggests that adopting these dietary strategies could potentially offer benefits akin to those provided by GLP-1 therapies in humans

Functional and phenotypic analyses confirm the induction of a pancreatic endocrine fate, including positive dithizone (DTZ) staining indicative of insulin production, as well as the upregulation of key pancreatic markers such as paired box gene 4 (PAX4), neurogenin 3 (NGN3), Isl-1, Some protocols utilized additional strategies like fibrin encapsulation, decellularized amniotic membrane [52] or 3D alginate encapsulation [51] scaffolds to enhance differentiation efficiency and mimic physiological conditions more closely