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Traditional herbal medicine and modern research have identified several plant compounds that support liver function through multiple mechanisms

Notably, ketoconazole abolished low-density lipoprotein (LDL)-induced reductase activity at submicromolar concentrations in various mammalian cell lines (IEC-6 cells, skin fibroblasts, HepG2, and Chinese hamster ovary cells), suggesting a potential application in cardiovascular disease [99]

Selective elevation of glutathione levels in target tissues with L-2-oxothiazolidine-4-carboxylate (OTC) protects against hyperoxia-induced lung damage in protein-energy malnourished rats: implications for a new treatment strategy

ACE2 on the other hand causes vasodilation and angiogenesis, and promotes anti-inflammatory, antioxidant and anti-apoptotic effects [40]

Thusly, ferroptosis is considered to be an important pathway leading to IS