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Given the activation of receptors as the only direct action of a neurotransmitter, beta-endorphin is a relatively well-known example of a peptide neurotransmitter primary transmitter at a synapse having highly specific interactions with opioid receptors in the central nervous system [34,35]

Although NNS reported insomnia (Insomnia Severity Index (ISI) and Pittsburgh Sleep Quality Index (PSQI)), there was no clear evidence of SSM and similar PSG and EEG spectral power findings as controls

Bethesda, MD, USA: 2023

The combined logic is: Three receptor pathways at once

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