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However, adverse effects such as uterine bleeding in pregnancy with the device and abnormal vaginal discharge after IUD insertion during IUD use have also been caused widespread concern [91]
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Persistence with antihypertensive medication: Australia-wide experience, 2004-2006

They suggest that DMA-induced effects may be due by an increased A anabolism (enhanced APP expression), although authors did not discard an alteration in the A degradation pathway (Zaraza et al., 2011)

J., Bressman, S
