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We hypothesize that irisin reduces lactate synthesis by inhibiting the HIF-1/LDHA pathway via SIRT1-mediated deacetylation and repairs mitochondrial function through the PGC-1/UCP2 pathway, ultimately improving neuronal damage

Multiple observational studies have found that individuals with low B12 are significantly more likely to report depressive symptoms, and intervention studies show that correcting the deficiency improves mood outcomes sometimes substantially

OHB protective pathways in Aralar-KO neurons and brain: an alternative to ketogenic diet

Through stable isotope tracing and chromatin-immunoprecipitation (ChIP) assay, we also found that ACTL6A promotes GSH synthesis by upregulating the rate-limiting enzyme GCLC as a co-transcription factor

Anyone experiencing high stress: Chronic stress depletes vitamin C and weakens immune function