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In a systematic review and meta-analysis of 13 controlled trials in 3629 patients with acute myocardial infarction, l-carnitine was beneficial for angina but had no effect on the development of heart failure or myocardial infarction [14]

aligning with our findings ( 5 Conclusion This study highlights the significant effect of the periodontal pathogen Pg on the TMA-TMAO pathway, primarily through modulation of FMO3 expression and regulation of hepatic lipid metabolism, compared to Fn and Sm

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Exclusion criteria were liver failure, a second malignancy, treatment with omega-3-fatty acids and the presence of a mental disorder precluding informed consent