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Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo

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The primary evidence comes from a 2015 study published in Annals of Clinical and Laboratory Science that used a rabbit osteoarthritis model

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Poplawska M, Dutta D, Jayaram M, Salifu M, Chong NS, Lim SH (2021) Intestinal pathophysiological abnormalities in steady state and after vaso-occlusive crisis in murine sickle cell disease