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For instance, cluster 1a in Figure 5A comprises proteins whose transcript levels are higher than those of proteins in cluster 1b

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Intramuscular injection into muscle is preferred over venous administration

However, in certain embodiments, where the effector is or comprises a polypeptide it is possible to recombinantly express the chimeric molecule as a single-chain fusion of the effector to a single chain antibody, or as a fusion of the effector to one chain of an antibody comprising more than one chain