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Additionally, based on human and experimental studies, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) contribute to keeping inflammation and neurogenic pain

A meta-nalysis showed that, compared with placebo/no intervention, the treatment with acetyl-l-carnitine significantly decreased the symptoms of depression, with fewer adverse events than those seen with established antidepressants [94]

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