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The research team also utilized epigenomic data (such as assay for transposase-accessible chromatin by sequencing (ATAC-seq)) to explore drug-induced changes in chromatin accessibility (Zou et al., 2021), discovering that epigenetic regulatory factors (such as Histone Deacetylases) may become synergistic targets to enhance drug sensitivity (Ramaiah et al., 2021)

To test this hypothesis, serum killing assays were carried out

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Methionine toxicity in the rat in relation to hepatic accumulation of S-adenosylmethionine: prevention by dietary stimulation of the hepatic transsulfuration pathway