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Users in a moderate deficit (300-500 calories/day) consistently report better outcomes than those eating at maintenance

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doi: 10.2174/1389557043403305

In the cortex, the activation of astrocytic CB1 receptors by exogenous cannabinoids impairs spatial working memory (Han et al., 2012
Zigman et al., 2006), where ghrelin has been shown to regulate dopamine release into the nucleus acumbens and the intake of palatable and rewarding diets (Abizaid et al., 2006
