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Notably, the experimental treatment significantly improved the OS of AML patients (24 months) and reduced common adverse events, such as neutropenia and infections, suggesting that 5-Aza-based therapies may provide meaningful clinical benefits in difficult-to-treat cancer patients [351]

doi: 10.1007/978-3-030-81388-8_6 15 CampitelliB

The hormones limited plasma half-life explains twice-to-thrice-daily conventional dosing, though emerging sustained-release matrices seek to mimic physiologic diurnal variation and attenuate post-dose tachycardia spikes

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Melanoma, Kills and reverses tumors and induces autophagy-dependent death in tumor cells