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Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig

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Studies have shown that AOD9604 acts through a combination of pathways, including beta-3 adrenergic receptor upregulation, cAMP-PKA-HSL signaling pathway activation, and acetyl-CoA carboxylase inhibition

The longest rodent toxicology study (90 days) found no organ damage, hepatotoxicity, or nephrotoxicity at doses up to 50mg/kg daily, establishing a NOAEL well above human trial doses
