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However, more recent data has challenged this hypothesized diffusion mechanism, showing that the transport of T4 and T3 across the cellular membrane into the cell requires active transport rather than passive diffusion

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Research indicates that HDL has some antidiabetic properties, as it can enhance insulin secretion, protect cells, and reduce insulin resistance, this implies that HDL-based therapies could be beneficial, to a certain degree, for type 2 diabetes patients who do not respond well to antidiabetic medications [173]

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