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1.2 The Therapeutic dilemma: limitations of current pharmacotherapy Despite the clear imperative to manage sleep effectively, clinicians often face a therapeutic dilemma because current pharmacological options remain suboptimal

Vendor technical sheets and primary studies report selectivity over related methyltransferases and enzymes of the NAD salvage pathway [1,6,7]
Those are legitimate goals

doi: 10.1038/jid.2012.399

Nature 476 (7360), 346350
