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Thus, melatonin administration in fibromyalgia can reduce pain and improve sleep quality, improving the overall quality of life [42]
An alternate possibility is that cytosolic NADPH manipulation ultimately affects matrix NADPH status through metabolite shuttles, which are used to convey reducing equivalents across the mitochondrial membranes by coupling mitochondrial redox reactions with their cytosolic counterparts (for example, using the transport of citrate to couple IDH2 and IDH1) (Taylor, 2017)
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From a proteomic point of view and using a series of multiplexed experiments, Ford et al
