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Table 1 summarizes some examples of disease-relevant proteins that are GS-ylated

PfB and BruB were shown to catalyze regioselective and stereoselective electrocyclization of polyene products from the respective PKS-NRPS, followed by either a [4+2] cycloaddition to give ()-PF-1018 ( 285 ), or [3,3]-Cope rearrangement to give 286 , respectively (Figure 62)
10.21037/tp.2019.09.09 [DOI] [PMC free article] [PubMed] 10.Singhi P, Malhi P

This personalized approach promises to enhance precision medicine by tailoring treatment plans to individual circadian profiles, thereby maximizing efficacy and minimizing adverse effects

In addition, the expression of LEAP2 is significantly upregulated following bariatric surgery, which is currently the most effective treatment for obesity (363)
