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The anti-apoptotic proteins (Bcl-2), inhibitor of apoptosis proteins (IAPs), and FLICE inhibitor proteins (FLIP) are upregulated in tumor cells, which contributes to their medication resistance (90)

Khelfa, A
Determinants of Human Plasma Glutathione Peroxidase (GPx-3) Expression

Vitamin B 12 status of patients treated with metformin: a cross-sectional cohort study

In both cases, GSH is the electron donor, which explains the tripeptide depletion after MEN treatment
