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The recommended daily intake is 2.3 mg for men and 1.8 mg for women ( Manganese deficiency can present with skin and hair alterations (such as dermatitis, impaired growth of hair and nails, and color changes in hair and beard), nausea and vomiting, ataxia and loss of equilibrium, altered carbohydrate and lipid metabolism, skeletal changes with defects and poor bone formation, impaired reproductive function, and reduced concentrations of clotting proteins (354)

doi: 10.1007/s40005-019-00459-7

N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition

Symptoms can include mental retardation, but it is not clear whether there is a straightforward inheritance pattern for this genetic abnormality