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Peptides and the blood-brain barrier

The rate of glutathione synthesis is controlled by several factors with the most important one being the feedback inhibition of -ECS by glutathione due to its binding to the glutamate site of the enzyme [300]

doi: 10.1126/science.3798116

Also, mitogen-activated protein kinase (MAPK) signaling is associated with mitochondrial homeostasis, MAPK1/3 potently inhibit mitochondrial biogenesis (Zhu et al., 2012)