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Description
Most pharmacological interventions for knee pain show diminishing returns over time

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For instance, silica nanoparticles (Nano-SiO2) significantly reduce NO levels and eNOS activity by activating the PI3K/Akt/mTOR signaling pathway, increase inflammatory responses, activate autophagy, and ultimately lead to ECD (Zhu et al., 2011)

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High levels may indicate histamine, allergy, leukemia, or infection
