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The reduction of beneficial bacteria ( lactic acid bacteria, bifidobacterium ) increases the risk of postoperative cognitive impairment, while surgical anesthesia exacerbates gut microbiota dysbiosis and shifts gut microbiota to a more toxic phenotype (Guyton and Alverdy, 2017)

J Biol Chem 248(19):68546861 Cavallini M, Casati A (2004) A prospective, randomized, blind comparison between saline, calcium gluconate and diphoterine for washing skin acid injuries in rats: effects on substance P and beta-endorphin release